What is phylogeny?
Phylogeny looks at "the history and the evolution of a species or group". Phylogenetic trees allow you to trace back and determine the common ancestor between two species [1].
Steps to Build a Phylogeny Tree
- The first step in building a tree is finding the amino acids for the protein in each species. Amino acids sequences can be found on ensemble. The sequences can be saved as Fasta to be used on ClustalOmega.
- Once the sequences are found, they can be aligned on clustalomega. The alignments can be used to detect amino acids that are conserved between species.
- The phylogeny tree is built using the alignment generated in previous step. An example of tree is shown in the figure below.
ABCD1 Phylogeny Tree
Conclusion
ABCD1 is conserved well between most mammals. It begins to drop off once we change to non mammal species and non- vertebrates.
Reference
[1] Gittleman, J. L. (2016, September 13). Phylogeny. Retrieved from https://www.britannica.com/science/phylogeny