What are protein interaction networks?
Protein interaction networks show us how different genes are interacting with each other. They can help us understand the causes of diseases as well as the development of drugs to cure them. Not all diseases are caused solely by the mutated gene, but the other genes that interact with it can also be affected and play a role in the disease [2].
Human ABCD1 Interaction Network
Protein Groups: The four main groups found in the protein interaction that are important in ALD were myelin, FA beta oxidation, peroxisome, and lipid transport [1].
Conclusion
ALD's main phenotype in the brain is the breakdown of myelin. Finding a gene helps regulate myelin indicates that these proteins might be down regulated due to an ABCD1 mutation. Other genes that were important to look for were proteins that regulate beta oxidation and lipid transport. Fatty acid toxicity is also responsible for the break down of myelin so it is important to know whether these genes are interacting with ABCD1. Peroxisome proteins consisted of a large majority of the interaction network. They are responsible for the bio-genesis and maintenance of the peroxisome [1].
Reference
[1] Welcome to STRING. (n.d.). Retrieved from https://string-db.org/cgi/input.pl?sessionId=qOLTIZEv4u1x&input_page_show_search=on
[2] Safari-Alighiarloo, N., Taghizadeh, M., Rezaei-Tavirani, M., Goliaei, B., & Peyvandi, A. A. (2014). Protein-protein interaction networks (PPI) and complex diseases. Retrieved May 10, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017556/www.ncbi.nlm.nih.gov/pmc/articles/PMC4017556/
[2] Safari-Alighiarloo, N., Taghizadeh, M., Rezaei-Tavirani, M., Goliaei, B., & Peyvandi, A. A. (2014). Protein-protein interaction networks (PPI) and complex diseases. Retrieved May 10, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4017556/www.ncbi.nlm.nih.gov/pmc/articles/PMC4017556/